Bone Abstracts

Ostearthritis (OA) is most common form of joint disease and one of the leading causes of disability and pain in elderly people worldwide. Historically, OA has been considered a non-inflammatory disease, but more recently studies revealed that inflammation is a risk factor associated with both progression of cartilage destruction and signs and symptoms of disease. Mean platelet volume (MPV), red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-...

Tendinopathy is a painful condition that occurs in and around tendons in response to overuse. The role of inflammation and inflammatory mediators in the development or progression of tendinopathy have been investigated in many studies, but it is still uncertain and controversial. Mean platelet volume (MPV), red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and RDW-to-platelet rat...

Osteoarthritis (OA) is a chronic, slowly progressive disease of the joints and is one of the most common causes of pain and disability in middle-aged and older people. The etiology and pathogenesis underlying this disease are poorly understood. Progranulin (PGRN), a secreted glycoprotein expressed in many cell types, has been linked to wide variety of biological processes. In recent years, increasing evidence suggests that PRGN stimulates chondrocyte proliferation and is consi...

The pathogenesis of tendinopathy remains unclear. Small integrin-binding ligand N-linked glycoproteins, a family of non-collagenous proteins including osteopontin (OPN) and bone sialoprotein (BSP), were initially thought to be limited to mineralized tissue but recent studies showed that they are more widely distributed and are expressed in nonmineralized tissues. Musculoskeletal tissue cells are categorized as the same functional unit developed from the mesenchymal stem cells....